期刊
ORAL DISEASES
卷 27, 期 5, 页码 1217-1225出版社
WILEY
DOI: 10.1111/odi.13663
关键词
dental; graft‐ versus‐ host disease; haematopoietic stem cell transplantation; longitudinal; mucosa
资金
- Stockholms Lans Landsting [20140451]
- Cancerfonden [CF 2014-2016, KF20130011, PR2013-0022]
- Wyeth [0468x1-3329]
- Astellas Pharma [SE-09RG-50]
- Marianne and Marcus Wallenberg Foundation [2013.0117]
The study found that using tacrolimus plus sirolimus as a prophylaxis for graft-versus-host disease following haematopoietic stem cell transplantation did not increase the incidence or severity of oral mucositis, nor did it prolong the healing time compared to cyclosporine plus methotrexate.
Objectives To determine whether treatment with tacrolimus plus sirolimus (Tac/Sir) as a prophylaxis for graft-versus-host disease worsens severe oral mucositis and delays healing compared to cyclosporine plus methotrexate (CsA/Mtx) following haematopoietic stem cell transplantation. Subjects and Methods The study comprised 141 patients: 73 randomized to receive Tac/Sir and 68 to receive CsA/Mtx. The oral mucositis assessment scale and toxicity grading according to WHO were used to assess the severity, peak and duration of oral mucositis from the day -3 to day 24 post-transplant. Results Eighty-seven patients developed oral mucositis in the first 24 days post-transplant. No significant difference in oral mucositis severity between the Tac/Sir and CsA/Mtx groups was observed. The peak oral mucositis score occurred on day 10 in both groups. Although oral mucositis scores had returned to baseline in the CsA/Mtx group on day 24 post-transplant, no significant difference compared with the Tac/Sir group was found. Conclusions The introduction of tacrolimus/sirolimus as a graft-versus-host disease prophylaxis in haematopoietic stem cell transplantation increased neither the incidence nor severity of oral mucositis compared with cyclosporine/methotrexate. Furthermore, oral mucositis healing was not prolonged and followed the same time pattern as cyclosporine/methotrexate.
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