期刊
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
卷 101, 期 -, 页码 60-74出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2016.03.008
关键词
Paget disease; Extramammary; Paget disease; Vulvar Paget disease; Vulvar carcinoma; Vulvar neoplasm; Perineal; Anogenital; Surgery; Imiquimod
In this review, we provide an overview of the clinical aspects, histopathology, molecular genetics, and treatment options for Vulvar Paget's Disease (VPD), a rare skin disease, most commonly found in postmenopausal Caucasian women. The underlying cause of VPD remains not well understood. VPD is rarely associated with an underlying urogenital, gastrointestinal or vulvar carcinoma. In approximately 25% of the cases, VPD is invasive; in these cases, the prognosis is worse than in non-invasive cases. Recurrence rates in invasive VPD are high: 33% in cases with clear margins, and even higher when surgical margins are not clear, regardless of invasion. Historically, surgical excision has been the treatment of choice. Recent studies show that imiquimod cream may be an effective and safe alternative. (C) 2016 The Authors. Published by Elsevier Ireland Ltd.
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