期刊
OCULAR IMMUNOLOGY AND INFLAMMATION
卷 30, 期 2, 页码 506-514出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/09273948.2020.1815797
关键词
Behcet disease; infliximab; interferon; uveitis
The study aimed to report the long-term results of biologic treatment for severe and refractory Behcet's uveitis, choosing a different biologic agent based on the uveitis clinical features. The study found that both IFN and IFX were effective and well tolerated in treating refractory BU.
Purpose To report long term results of biologic treatment of severe and refractory Behcet's uveitis (BU) choosing a different biologic agent according to the uveitis clinical features. Methods Retrospective cohort of patients with BU refractory to conventional therapy, who received Interferon (IFN) alpha-2a or Infliximab (IFX) for at least 3 months. Results Twenty-two patients were included (mean age 29 +/- 10 years, 63% males); Fifteen received IFN and 7 IFX, for a mean treatment period of 30 +/- 24(SD) months. Twenty (90%) patients discontinued treatment, in most cases for complete remission (77%). Seven patients (32%) showed relapses during treatment and five (23%) after discontinuation. Visual acuity improved significantly in IFN group and all eyes showed a significant decrease in central macular thickness at 12 months. Conclusions Both IFX and IFN Alpha-2a were effective and well tolerated in the treatment of refractory BU using a customized approach based on the uveitis features.
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