期刊
NUTRITIONAL NEUROSCIENCE
卷 25, 期 4, 页码 835-845出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/1028415X.2020.1815332
关键词
Vitamin D supplementation; autism spectrum disorders; children; randomized controlled trials; meta-analysis; systematic review; hyperactivity; docosahexaenoic acid; core symptoms
资金
- Department of Science and Technology [171100310200]
- Health Department of Henan Province, China
- Swedish Research Council, Sweden [2018-02667, 2018-02682]
- ALF [ALFGBG-813291]
- Swedish Research Council [2018-02667, 2018-02682] Funding Source: Swedish Research Council
- Vinnova [2018-02667, 2018-02682] Funding Source: Vinnova
This meta-analysis suggests that vitamin D supplementation has limited efficacy in improving symptoms of Autism Spectrum Disorder (ASD) in children, with only a small but significant improvement observed in hyperactivity.
Objective:The effect of vitamin D supplementation on the risk of Autism Spectrum Disorder (ASD) is conflicting. The aim of this study was to estimate the efficacy of vitamin D supplementation on ASD in children. Methods:We conducted a meta-analysis of randomized controlled trials (RCTs) in which vitamin D supplementation was used as a therapy in children with ASD. The PubMed, PsychINFO, Cochrane CENTRAL library, Web of Science, and Cinahl databases were searched from inception to March 20, 2019, for all publications on vitamin D and ASD with no restrictions. Studies involving individuals aged <18 years diagnosed with ASD and with all functional outcomes assessed by measurement scales for ASD were included. Mean differences were pooled, and a meta-analysis was performed using a random-effects model due to differences between the individual RCTs. Results:There were five RCTs with 349 children with ASD in the review, of which three RCTs were included in the meta-analysis. Vitamin D supplementation indicated a small but significant improvement in hyperactivity scores (pooled MD: -3.20; 95% CI: [-6.06, -0.34]) with low heterogeneity (I-2 = 10%,p = 0.33), but there were no other statistically significant differences in ASD symptoms between groups as measured by validated scales. Conclusion:Vitamin D supplementation appears to be beneficial for hyperactivity but not for core symptoms or other co-existing behaviors and conditions of ASD. Future RCTs with large sample sizes examining the effect of vitamin D supplementation on ASD among individuals with low serum vitamin D levels at baseline are needed.
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