期刊
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
卷 107, 期 -, 页码 54-71出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.critrevonc.2016.08.006
关键词
Cancer stem cells; Drug resistance; Molecular markers; Gastrointestinal tumors
资金
- Ramon y Cajal Merit Award from the Ministerio de Economia y Competitividad, Spain
- Clinic and Laboratory Integration Program (CLIP) grant from the Cancer Research Institute, NY
Cancer stem cells (CSCs) are a very heterogeneous subpopulation of stem-like cancer cells that have been identified in many cancers, including leukemias and solid tumors. It is believed that CSCs drive tumor growth, malignant behavior and are responsible for the initiation of metastatic spread. In addition, CSCs have been implicated in chemotherapy and radiotherapy resistance. Current evidence supports the theory that CSCs share at least two main features of normal stem cells: self-renewal and differentiation, properties that contribute to tumor survival even in the presence of aggressive chemotherapy; however, the mechanism(s) governing the unique biology of CSCs remain unclear. In the field of gastrointestinal cancer, where we face very low survival rates across different tumor types, unraveling the role of CSCs in gastrointestinal tumors should improve our knowledge of cancer biology and chemoresistance, ultimately benefiting patient survival. Towards this end, much effort is being invested in the characterization of CSCs as a means of overcoming drug resistance and controlling metastatic spread. In this review we will cover the concept of CSCs, the current evidence for CSCs in gastrointestinal tumors and future research directions. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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