期刊
NUCLEIC ACIDS RESEARCH
卷 48, 期 19, 页码 10768-10784出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkaa787
关键词
-
资金
- Ministry of Science and Technology of China [2013CB945201]
- National Natural Science Foundation of China [31871286, 81872015, 31701102, 81702800, 81502438, 81902889]
- Ministry of Education fund innovation team [IRT 13101]
- Foundation for Special Professor of Liaoning Province
- China Postdoctoral Science Foundation [2019M651164]
Estrogen receptor alpha (ER alpha) signaling pathway is essential for ER alpha-positive breast cancer progression and endocrine therapy resistance. Bromodomain PHD Finger Transcription Factor (BPTF) associated protein of 18kDa (BAP18) has been recognized as a crucial H3K4me3 reader. However, the whole genomic occupation of BAP18 and its biological function in breast cancer is still elusive. Here, we found that higher expression of BAP18 in ER alpha-positive breast cancer is positively correlated with poor prognosis. ChIP-seq analysis further demonstrated that the half estrogen response elements (EREs) and the CCCTC binding factor (CTCF) binding sites are the significant enrichment sites found in estrogen-induced BAP18 binding sites. Also, we provide the evidence to demonstrate that BAP18 as a novel co-activator of ER alpha is required for the recruitment of COMPASS-like core subunits to the cis-regulatory element of ER alpha target genes in breast cancer cells. BAP18 is recruited to the promoter regions of estrogen-induced genes, accompanied with the enrichment of the lysine 4-trimethylated histone H3 tail (H3K4me3) in the presence of E2. Furthermore, BAP18 promotes cell growth and associates the sensitivity of antiestrogen in ER alpha-positive breast cancer. Our data suggest that BAP18 facilitates the association between ER alpha and COMPASS-like core subunits, which might be an essential epigenetic therapeutic target for breast cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据