期刊
NUCLEIC ACIDS RESEARCH
卷 49, 期 D1, 页码 D468-D474出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkaa796
关键词
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资金
- National Key Research and Development Program of China [2017YFA0700403]
- National Natural Science Foundation of China (NSFC) [31822030, 31801154, 31771458]
- China Postdoctoral Science Foundation [2017M622455, 2019T120664]
- National Natural Science Foundation of China [31822030]
TCRdb is a comprehensive human TCR sequences database, containing over 277 million highly reliable TCR sequences from over 8265 TCR-Seq samples, with unique features including a powerful search function and interactive data visualization charts for comparing TCR repertoire in different samples. It will serve as a valuable resource for the research and application community of T cell immunology.
T cells and the T-cell receptor (TCR) repertoire play pivotal roles in immune response and immunotherapy. TCR sequencing (TCR-Seq) technology has enabled accurate profiling TCR repertoire and currently a large number of TCR-Seq data are available in public. Based on the urgent need to effectively reuse these data, we developed TCRdb, a comprehensive human TCR sequences database, by a uniform pipeline to characterize TCR sequences on TCR-Seq data. TCRdb contains more than 277 million highly reliable TCR sequences from over 8265 TCR-Seq samples across hundreds of tissues/clinical conditions/cell types. The unique features of TCRdb include: (i) comprehensive and reliable sequences for TCR repertoire in different samples generated by a strict and uniform pipeline of TCRdb; (ii) powerful search function, allowing users to identify their interested TCR sequences in different conditions; (iii) categorized sample metadata, enabling comparison of TCRs in different sample types; (iv) interactive data visualization charts, describing the TCR repertoire in TCR diversity, length distribution and V-J gene utilization. The TCRdb database is freely available at http://bioinfo.life.hust.edu.cn/TCRdb/ and will be a useful resource in the research and application community of T cell immunology.
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