期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 116, 期 -, 页码 74-88出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2020.06.004
关键词
Schizophrenia; Negative symptoms; Apathy; Avolition; Diminished expression; Pathophysiology; Behavioral; Neuroimaging
资金
- Swiss National Science Foundation [P2SKP3_178175, 10001CL_169783/1]
- Banque Nationale Fellowship of the MNI
- Swiss National Science Foundation (SNF) [10001CL_169783, P2SKP3_178175] Funding Source: Swiss National Science Foundation (SNF)
Negative symptoms of schizophrenia comprise a group of severe symptoms contributing to high disease burden and poor long-term prognosis. Conceptual work has shown that these symptoms can be mapped onto, at least, two distinct dimensions: apathy including the domains avolition, asociality and anhedonia, and diminished expression including the domains blunted affect and alogia. Growing evidence suggest that these dimensions have partly distinct behavioral, cognitive and neural correlates. Nonetheless, modulation and treatment of specific processes and brain correlates related to these negative symptom dimensions through behavioral, pharmacological, and brain stimulation interventions remains poorly understood. Here, we address this question by employing an integrative approach and comprehensively synthesizing the current literature on neuroimaging, behavior and clinical studies of both negative symptom dimensions. While considerable progress has been made, it remains an open challenge to develop integrative mechanistic pathophysiological models for apathy and diminished expression. We conclude that such multi-level frameworks are key for the development of new biological and psychosocial treatments and may advance progress towards an individualized treatment of negative symptoms.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据