4.5 Article

The Geometry of Limb Motor Innervation is Controlled by the Dorsal-Ventral Compartment Boundary in the Chick Limbless Mutant

期刊

NEUROSCIENCE
卷 450, 期 -, 页码 29-47

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2020.09.054

关键词

limbless; dorsal limb transformation; medial and lateral LMC; dorsal-ventral axon choice; limb motor innervation

资金

  1. National Institutes of Health (NIH) [R01 HD073104, R01 HD091846]
  2. NIH
  3. Muscular Dystrophy Association
  4. New York State Spinal Cord Injury Research Program
  5. Howard Hughes Medical Institute Research Resource Program for Medical Schools
  6. Center for Motor Neuron Biology and Disease at Columbia University

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Precise control of limb muscles, and ultimately of limb movement, requires accurate motor innervation. Motor innervation of the vertebrate limb is established by sequential selection of trajectories at successive decision points. Motor axons of the lateral motor column (LMC) segregate at the base of the limb into two groups that execute a choice between dorsal and ventral tissue: medial LMC axons innervate the ventral limb, whereas lateral LMC axons innervate the dorsal limb. We investigated how LMC axons are targeted to the limb using the chick mutant limbless (ll), which has a dorsal transformation of the ventral limb mesenchyme. In ll the spatial pattern of motor projections to the limb is abnormal while their targeting is normal. While extensive, the dorsal transformation of the ll ventral limb mesenchyme is incomplete whereas the generation, specification and targeting of spinal motor neurons are apparently unaffected. Thus, the dorsal-ventral motor axon segregation is an active choice that is independent of the ratio between dorsal and ventral tissue but dependent on the presence of both tissues. Therefore, the fidelity of the motor projections to the limb depends on the presence of both dorsal and ventral compartments, while the geometry of motor projections is controlled by the position of limb dorsal-ventral compartment boundary. (c) 2020 IBRO. Published by Elsevier Ltd. All rights reserved.

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