期刊
NEUROPSYCHOPHARMACOLOGY
卷 46, 期 2, 页码 432-441出版社
SPRINGERNATURE
DOI: 10.1038/s41386-020-00873-8
关键词
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资金
- Melbourne Research Scholarship
- National Health and Medical Research Council-Australian Research Council (NHMRC-ARC) Dementia Research Development Fellowship [1111552]
- NHMRC Principal Research Fellowship [1117148]
- National Health and Medical Research Council of Australia [1111552, 1117148] Funding Source: NHMRC
This study adapted the Posner task, commonly used in humans, for mice using touchscreen technology, showing that mice are a valid animal model for studying attention orienting neural mechanisms. Mice responded more quickly and accurately to valid cues, and could be trained to voluntarily maintain their nose-poke on a touchscreen for attention orienting tasks.
Atypical attention orienting has been found to be impaired in many neuropsychological disorders, but the underlying neural mechanism remains unclear. Attention can be oriented exogenously (i.e., driven by salient stimuli) or endogenously (i.e., driven by one's goals or intentions). Genetic mouse models are useful tools to investigate the neurobiology of cognition, but a well-established assessment of attention orienting in mice is missing. This study aimed to adapt the Posner task, a widely used attention orienting task in humans, for use in mice using touchscreen technology and to test the effects of two attention-modulating drugs, methylphenidate (MPH) and atomoxetine (ATX), on the performance of mice during this task. In accordance with human performance, mice responded more quickly and more accurately to validly cued targets compared to invalidly cued targets, thus supporting mice as a valid animal model to study the neural mechanisms of attention orienting. This is the first evidence that mice can be trained to voluntarily maintain their nose-poke on a touchscreen and to complete attention orienting tasks using exogenous peripheral cues and endogenous symbolic cues. The results also showed no significant effects of MPH and ATX on attention orienting, although MPH improved overall response times in mice during the exogenous orienting task. In summary, the current study provides a critical translational task for assessing attention orienting in mice and to investigate the effects of attention-modulating drugs on attention orienting.
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