期刊
NEURON
卷 108, 期 6, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.neuron.2020.09.032
关键词
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资金
- ERC [StG 678790 NEWRON, MSCA 800027 FindMEMO]
- Pasteur Weizmann Council
- Ecole Doctorale Cerveau-Cognition-Comportement (ED3C) [158, 2802/2017]
- Pasteur-Roux fellowship
How are distinct memories formed and used for behavior? To relate neuronal and behavioral discrimination during memory formation, we use in vivo 2-photon Ca2+ imaging and whole-cell recordings from hippocampal subregions in head-fixed mice performing a spatial virtual reality task. We find that subthreshold activity as well as population codes of dentate gyrus neurons robustly discriminate across different spatial environments, whereas neuronal remapping in CA1 depends on the degree of difference between visual cues. Moreover, neuronal discrimination in CA1, but not in the dentate gyrus, reflects behavioral performance. Our results suggest that CA1 weights the decorrelated information from the dentate gyrus according to its relevance, producing a map of memory representations that can be used by downstream circuits to guide learning and behavior.
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