期刊
NEURON
卷 108, 期 3, 页码 551-+出版社
CELL PRESS
DOI: 10.1016/j.neuron.2020.07.021
关键词
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资金
- C.V. Starr Foundation Fellowship
- NIH [R00 EY025768, R01 MH118929, R01 EB026953, R01 HD071686, R01 EY022928, P30 EY008098]
- Brain and Behavior Research Foundation
- NSF [1747452]
- Richard King Mellon Foundation Presidential Fellowship in the Life Sciences
- NSF NCS [1734916/1954107, BCS1533672]
- NIH CRCNS [R01 NS105318]
- Simons Foundation [543065]
An animal's decision depends not only on incoming sensory evidence but also on its fluctuating internal state. This state embodies multiple cognitive factors, such as arousal and fatigue, but it is unclear how these factors influence the neural processes that encode sensory stimuli and form a decision. We discovered that, unprompted by task conditions, animals slowly shifted their likelihood of detecting stimulus changes over the timescale of tens of minutes. Neural population activity from visual area V4, as well as from prefrontal cortex, slowly drifted together with these behavioral fluctuations. We found that this slow drift, rather than altering the encoding of the sensory stimulus, acted as an impulsivity signal, overriding sensory evidence to dictate the final decision. Overall, this work uncovers an internal state embedded in population activity across multiple brain areas and sheds further light on how internal states contribute to the decision-making process.
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