期刊
CRITICAL CARE MEDICINE
卷 44, 期 12, 页码 2241-2250出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/CCM.0000000000002007
关键词
acute kidney injury; critical care outcomes; epidemiology; pediatric intensive care units; renal replacement therapy; sepsis
资金
- Endowed Chair, Department of Anesthesia and Critical Care, University of Pennsylvania Perelman School of Medicine
- Center for Pediatric Clinical Effectiveness at The Children's Hospital of Philadelphia
- U.K. National Institute of Health (NIHR) Clinical Research Network
- Southampton NIHR Wellcome Trust Clinical Research Facility
- Children's Hospital of Philadelphia Center for Pediatric Clinical Effectiveness
- Baxter
- National Institutes of Health (NIH)
- Therabron
- CareFusion
- Food and Drug Administration
- Thermo-Fisher Scientific
- NIH [K12HD047349-10]
Objectives: The prevalence of septic acute kidney injury and impact on functional status of PICU survivors are unknown. We used data from an international prospective severe sepsis study to elucidate functional outcomes of children suffering septic acute kidney injury. Design: Secondary analysis of patients in the Sepsis PRevalence, OUtcomes, and Therapies point prevalence study: acute kidney injury was defined on the study day using Kidney Disease Improving Global Outcomes definitions. Patients with no acute kidney injury or stage 1 acute kidney injury (no/mild acute kidney injury) were compared with those with stage 2 or 3 acute kidney injury (severe acute kidney injury). The primary outcome was a composite of death or new moderate disability at discharge defined as a Pediatric Overall Performance Category score of 3 or higher and increased by 1 from baseline. Setting: One hundred twenty-eight PICUs in 26 countries. Patients: Children with severe sepsis in the Sepsis PRevalence, OUtcomes, and Therapies study. Interventions: None. Measurements and Main Results: One hundred two (21%) of 493 patients had severe acute kidney injury. More than twice as many patients with severe acute kidney injury died or developed new moderate disability compared with those with no/mild acute kidney injury (64% vs 30%; p < 0.001). Severe acute kidney injury was independently associated with death or new moderate disability (adjusted odds ratio, 2.5; 95% CI, 1.5-4.2; p = 0.001) after adjustment for age, region, baseline disability, malignancy, invasive mechanical ventilation, albumin administration, and the pediatric logistic organ dysfunction score. Conclusions: In a multinational cohort of critically ill children with severe sepsis and high mortality rates, septic acute kidney injury is independently associated with further increased death or new disability.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据