期刊
NEUROLOGICAL SCIENCES
卷 42, 期 2, 页码 723-726出版社
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10072-020-04743-5
关键词
Normal pressure hydrocephalus (NPH); Parkinsonism; I-123-FP-CIT-SPECT; MRI
资金
- Italian Ministry of Health [RF- 2013-02355908]
iNPH is a debated condition with controversial pathogenesis and diagnostic criteria. Parkinsonian signs are frequently reported, which may or may not be related to an underlying neurodegenerative parkinsonism, and distinguishing between the two is crucial for predicting long-term response to cerebrospinal fluid drainage.
Idiopathic normal pressure hydrocephalus (iNPH) is a debated entity with controversial pathogenesis, diagnostic criteria, and predictors of response after ventriculoperitoneal shunt (VPS). Parkinsonian signs are frequently reported in the clinical picture, sometimes due to the coexistence of an underlying neurodegenerative parkinsonism and sometimes in the absence thereof. To distinguish these two scenarios is crucial, since they may carry different long-term response to CSF drainage.I-123-FP-CIT-SPECT was believed to be helpful in this regard, however its role in predicting surgical outcome has been disputed. We illustrate a patient presented with gait disturbance, urinary incontinence, and asymmetrical parkinsonian signs, who underwent a 3T brain MRI and a(123)I-FP-CIT-SPECT. VPS was performed. The patient repeated a(123)I-FP-CIT-SPECT, 18 months after the operation, and was clinically followed up for 24 months. Our patient displayed clinical and radiological criteria for iNPH and an abnormal asymmetrical uptake in(123)I-FP-CIT-SPECT, consistent with her asymmetrical parkinsonism. However, the organization of the substantia nigra studied with iron-sensitive sequences in 3T brain MRI scan appeared intact. The patient revealed an improvement both clinically and in(123)I-FP-CIT-SPECT at postsurgical follow-up. Our report suggests that abnormal(123)I-FP-CIT-SPECT may not necessarily reveal an overlap with neurodegenerative parkinsonism; its partial reversibility may suggest that the mechanical effect exerted on the striatum by ventriculomegaly ultimately leads to downregulation of dopaminergic transporters which may improve after VPS.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据