期刊
NEUROIMAGE
卷 220, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2020.117079
关键词
Designer receptors exclusively activated by designer drugs; Magnetic resonance imaging; Clozapine; Clozapine-N-Oxide; Striatum; Drd1-receptor-expressing striatal projection neurons
资金
- Inserm
- Sorbonne University
- Fondation pour la Recherche Medicale (FRM) [DPA20140629798]
- ANR [ANR-16-CE16-0018]
- Fondation de France [00086313]
- Federation pour la recherche sur le cerveau (FRC)
- Rotary Espoir en Tete
- DIM Cerveau et Pensee Region Ile-de-France
- Uehara Memorial Foundation [201430033]
- Fyssen Foundation fellowship
- Idex Paris-Saclay
- Agence Nationale de la Recherche (ANR) [ANR-16-CE16-0018] Funding Source: Agence Nationale de la Recherche (ANR)
Abnormal structural and functional connectivity in the striatum during neurological disorders has been reported using functional magnetic resonance imaging (fMRI), although the effects of cell-type specific neuronal stimulation on fMRI and related behavioral alterations are not well understood. In this study, we combined DREADD technology with fMRI (chemo-fMRI) to investigate alterations of spontaneous neuronal activity. These were induced by the unilateral activation of dopamine D1 receptor-expressing neurons (D1-neurons) in the mouse dorsal striatum (DS). After clozapine (CLZ) stimulation of the excitatory DREADD expressed in Dl-neurons, the fractional amplitude of low frequency fluctuations (fALFF) increased bilaterally in the medial thalamus, nucleus accumbens and cortex. In addition, we found that the gamma-band of local field potentials was increased in the stimulated DS and cortex bilaterally. These results provide insights for better interpretation of cell type-specific activity changes in fMRI.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据