期刊
NEUROBIOLOGY OF AGING
卷 94, 期 -, 页码 265-270出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2020.06.004
关键词
Alzheimer's disease; THY-Tau22; Tau; EEG; Epilepsy; Seizures
资金
- Hauts-de-France (PARTEN-AIRR, COGNADORA)
- ANR (ADORASTrAU)
- CoEN [5008]
- Programs d'Investissements d'Avenir LabEx (excellence laboratory) DISTALZ (Development of Innovative Strategies for a Transdisciplinary approach to ALZheimer's disease)
- Fondation pour la Recherche Medicale
- France Alzheimer/Fondation de France
- FHU VasCog research network (Lille, France)
- Fondation Vaincre Alzheimer
- Fondation Plan Alzheimer
- Inserm, CNRS, Universite Lille, Lille Metropole Communaute Urbaine, DN2M
- Fondation pour la Recherche Medicale [SPF20160936000]
- US National Institutes of Health (NIH) [NS103740, NS065957]
- CURE foundation (CURE Catalyst Award)
- New Jersey Commission for Brain Injury Research
Epileptic seizures constitute a significant comorbidity of Alzheimer's disease (AD), which are recapitulated in transgenic mouse models of amyloidogenesis. Here, we sought to evaluate the potential role of tau pathology regarding seizure occurrence. To this end, we performed intra-hippocampal electroencephalogram (EEG) recordings and PTZ (pentylenetetrazol) seizure threshold tests in THY-Tau22 transgenic mice of AD-like tau pathology. We demonstrate that despite a lack of spontaneous epileptiform activity in Tau22 mice, the animals display increased PTZ-induced seizure susceptibility and mortality. The increased propensity for induced seizures in THY-Tau22 mutants correlates with astrogliosis and increased expression of adenosine kinase, consistent with increased network excitability. These data support an impact of tau pathology toward AD-associated seizures and suggest that tau pathology may contribute to seizure generation in AD independent of A beta pathology. (C) 2020 Elsevier Inc. All rights reserved.
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