期刊
NATURE STRUCTURAL & MOLECULAR BIOLOGY
卷 27, 期 10, 页码 967-+出版社
NATURE RESEARCH
DOI: 10.1038/s41594-020-0487-4
关键词
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资金
- NIH [S10OD023410, R01 GM122776]
- Lalor Foundation Postdoctoral Fellowship
- JSPS Overseas Research Fellowship
- Azabu University Research Services Division, Ministry of Education, Culture, Sports, Science and Technology (MEXT) Supported Program for the Private University Research Branding Project (2016-2019)
- Uehara Memorial Foundation Research Incentive Grant (2018)
- Albert J. Ryan Fellowship
- National Institute of Health (NIH) [DP2 GM119134]
- March of Dimes Prematurity Research Centre Collaborative Grant [22-FY14-470]
- [19K21196]
ERV-specific enhancer-based networks regulate species-specific transcriptomes in mammalian spermatogenesis. Gene regulation in the germline ensures the production of high-quality gametes, long-term maintenance of the species and speciation. Male germline transcriptomes undergo dynamic changes after the mitosis-to-meiosis transition and have been subject to evolutionary divergence among mammals. However, the mechanisms underlying germline regulatory divergence remain undetermined. Here, we show that endogenous retroviruses (ERVs) influence species-specific germline transcriptomes. After the mitosis-to-meiosis transition in male mice, specific ERVs function as active enhancers to drive germline genes, including a mouse-specific gene set, and bear binding motifs for critical regulators of spermatogenesis, such as A-MYB. This raises the possibility that a genome-wide transposition of ERVs rewired germline gene expression in a species-specific manner. Of note, independently evolved ERVs are associated with the expression of human-specific germline genes, demonstrating the prevalence of ERV-driven mechanisms in mammals. Together, we propose that ERVs fine-tune species-specific transcriptomes in the mammalian germline.
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