期刊
NATURE REVIEWS MICROBIOLOGY
卷 19, 期 2, 页码 77-94出版社
NATURE PORTFOLIO
DOI: 10.1038/s41579-020-0438-4
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资金
- Fulbright United States Scholar Program (US Fulbright Scholar Award)
- Human Frontier Science Program (HFSP) [LT000195/2018-L]
- Transatlantic Networks of Excellence Award from the Leducq Foundation [17CVD01]
- JPI (A healthy diet for a healthy life) [2017-01996_3]
- AFA insurances
- Swedish Research Council [2019-01599]
- Swedish Heart Lung Foundation [20180600]
- Knut and Alice Wallenberg Foundation [2017.0026]
- Novo Nordisk Foundation [NNF19OC0057271, NNF17OC0028232, NNF15OC0016798]
- Swedish government [ALFGBG-718101]
- Swedish county councils [ALFGBG-718101]
- ERC Consolidator Grant (European Research Council) [615362-METABASE]
- Swedish ALF-agreement [ALFGBG-718101]
- Swedish Research Council [2019-01599] Funding Source: Swedish Research Council
The gut microbiota influences host physiology through the production of various metabolites. By studying microbial metabolites, researchers have identified potential microbial targets relevant for host health, despite the challenges of understanding host-microbiota interactions.
The gut microbiota contributes to host physiology through the production of a myriad of metabolites. In this Review, Backhed and colleagues discuss the major classes of microbial metabolites, highlight examples of how microbial metabolites affect host health and provide a potential framework for integration of discovery-based metabolite studies with mechanistic work. The gut microbiota contributes to host physiology through the production of a myriad of metabolites. These metabolites exert their effects within the host as signalling molecules and substrates for metabolic reactions. Although the study of host-microbiota interactions remains challenging due to the high degree of crosstalk both within and between kingdoms, metabolite-focused research has identified multiple actionable microbial targets that are relevant for host health. Metabolites, as the functional output of combined host and microorganism interactions, provide a snapshot in time of an extraordinarily complex multi-organism system. Although substantial work remains towards understanding host-microbiota interactions and the underlying mechanisms, we review the current state of knowledge for each of the major classes of microbial metabolites with emphasis on clinical and translational research implications. We provide an overview of methodologies available for measurement of microbial metabolites, and in addition to discussion of key challenges, we provide a potential framework for integration of discovery-based metabolite studies with mechanistic work. Finally, we highlight examples in the literature where this approach has led to substantial progress in understanding host-microbiota interactions.
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