期刊
NATURE MEDICINE
卷 26, 期 11, 页码 1694-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41591-020-1070-6
关键词
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资金
- Bill & Melinda Gates Foundation [INV-006131]
- Janssen Vaccines Prevention BV
- Ragon Institute of MGH, MIT and Harvard
- Mark and Lisa Schwartz Foundation
- Massachusetts Consortium on Pathogen Readiness
- National Institutes of Health [OD024917, AI129797, AI124377, AI128751, AI126603, AI007387, AI146779, AI135098, OD011092, OD025002]
- Department of Health and Human Services Biomedical Advanced Research and Development Authority [HHS0100201700018C]
- Emergent Ventures, Mercatus Center at George Mason University
- Bill and Melinda Gates Foundation [INV-006131] Funding Source: Bill and Melinda Gates Foundation
Coronavirus disease 2019 (COVID-19) in humans is often a clinically mild illness, but some individuals develop severe pneumonia, respiratory failure and death(1-4). Studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in hamsters(5-7)and nonhuman primates(8-10)have generally reported mild clinical disease, and preclinical SARS-CoV-2 vaccine studies have demonstrated reduction of viral replication in the upper and lower respiratory tracts in nonhuman primates(11-13). Here we show that high-dose intranasal SARS-CoV-2 infection in hamsters results in severe clinical disease, including high levels of virus replication in tissues, extensive pneumonia, weight loss and mortality in a subset of animals. A single immunization with an adenovirus serotype 26 vector-based vaccine expressing a stabilized SARS-CoV-2 spike protein elicited binding and neutralizing antibody responses and protected against SARS-CoV-2-induced weight loss, pneumonia and mortality. These data demonstrate vaccine protection against SARS-CoV-2 clinical disease. This model should prove useful for preclinical studies of SARS-CoV-2 vaccines, therapeutics and pathogenesis. A single immunization with an adenovirus vector-based vaccine expressing a stabilized SARS-CoV-2 spike protein induces protection against SARS-CoV-2-induced weight loss, pneumonia and mortality in hamsters.
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