期刊
NATURE BIOTECHNOLOGY
卷 39, 期 2, 页码 -出版社
NATURE RESEARCH
DOI: 10.1038/s41587-020-0679-9
关键词
-
资金
- NIH
- NSF
- Gatsby Foundation
- Fresenius Foundation
- Wiegers Foundation
- Grosfeld Foundation
- NOMIS Foundation
- Walter V. and Idun Berry Postdoctoral Fellowship
- NARSAD Young Investigator Grant
- University of Minnesota's MnDRIVE (Minnesota's Discovery, Research and Innovation Economy) initiative [NS94668]
- [K99 DA050662]
- [F32 NS106764]
- [R01 NS112518]
- [R01 NS104071]
Achieving precise control over specific neural circuits in the deep brain without surgery is possible using ChRmine, enabling behavioral modulation and optogenetic control of neural activity at unprecedented depths.
Achieving temporally precise, noninvasive control over specific neural cell types in the deep brain would advance the study of nervous system function. Here we use the potent channelrhodopsin ChRmine to achieve transcranial photoactivation of defined neural circuits, including midbrain and brainstem structures, at unprecedented depths of up to 7 mm with millisecond precision. Using systemic viral delivery of ChRmine, we demonstrate behavioral modulation without surgery, enabling implant-free deep brain optogenetics. Optogenetic control of neural activity in the deep brain is achieved without intracranial surgery using ChRmine.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据