期刊
NATURAL PRODUCT RESEARCH
卷 35, 期 24, 页码 5765-5772出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2020.1834551
关键词
Polyhydroxysteroids; asterosaponins; starfish; Asterias microdiscus; cytotoxicity; cell proliferation; clonogenic assay
资金
- RSF (Russian Science Foundation) [20-14-00040]
- Russian Science Foundation [20-14-00040] Funding Source: Russian Science Foundation
Two new natural compounds, sulfated polyhydroxysteroid microdiscusol G (1) and polyhydroxysteroid bioside microdiscusoside A (2), along with eight previously known polar steroid substances, were isolated from the Arctic starfish Asterias microdiscus. Compounds 9 and 10 showed cytotoxic effects against normal and cancer cells, while compounds 5, 7, and 8 were inactive or less active in the same experiments.
Two new natural compounds, sulfated polyhydroxysteroid, microdiscusol G (1), and polyhydroxysteroid bioside, microdiscusoside A (2), along with eight previously known polar steroid substances3-10, were isolated from the Arctic starfishAsterias microdiscus. The structures of1and2have been elucidated by extensive 1D and 2D NMR spectroscopy and HRESIMS techniques. The 28-sulfooxy-24-methylcholestane side chain in1has been found among starfish steroid metabolites for the first time. Steroid saponins9and10exhibited cytotoxic effects against normal cells JB6 Cl41 and cancer cells HT-29, MDA-MB-231, THP-1, and Raji and effectively suppressed cell proliferation and colony formation of cancer cells HT-29 and MDA-MB-231 in non-toxic concentrations. Compounds5,7, and8were inactive or less active in the same experiments.
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