Hierarchical cage-frame type nanostructure of CeO2for bio sensing applications: from glucose to protein detection

Self-assembled hierarchical nanostructures are slowly superseding their conventional counterparts for use in biosensors. These morphologies show high surface area with tunable porosity and packing density. Modulating the interfacial interactions and subsequent particle assembly occurring at the water-and-oil interface in inverse miniemulsions, are amongst the best strategies to stabilize various type of hollow nanostructures. The paper presents a successful protocol to obtain CeO(2)hollow structures based biosensors that are useful for glucose to protein sensing. The fabricated glucose sensor is able to deliver high sensitivity (0.495 mu A cm(-2)nM(-1)), low detection limit (6.46 nM) and wide linear range (0 nM to 600 nM). CeO(2)based bioelectrode can also be considered as a suitable candidate for protein sensors. It can detect protein concentrations varying from 0 to 30 mu M, which is similar or higher than most reports in the literature. The limit of detection (LOD) for protein was similar to 0.04 mu M. Therefore, the hollow CeO(2)electrodes, with excellent reproducibility, stability and repeatability, open a new area of application for cage-frame type particles.

Automated summary

The study has successfully developed a biosensor based on CeO(2) hollow structures, which exhibits high sensitivity, low detection limit and wide linear range for detecting glucose and proteins. The CeO(2) bioelectrode can also detect a wide range of protein concentrations with high accuracy.