期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 29, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.nano.2020.102259
关键词
Colistin; Amikacin; NLC; AMR; Pulmonary infection
资金
- Department of Economic Development and Infrastructure of the Basque Government budget, through the Hazitek business R&D support program [ZE-2017/00014]
- European Regional Development Fund (ERDF)
- 8th Joint Transnational Call for Proposals for European Innovative Research & Technological Development Projects in Nanomedicine
Sodium colistimethate (SCM) and amikacin (AMK) are among the few antibiotics effective against resistant P. aeruginosa, K. pneumoniae and A. baumannii; however, their toxicity severely limits their use. Enclosing antibiotics into nanostructured lipid carriers (NLC) might decrease drug toxicity and improve antibiotic disposition. In this work, SCM or AMK was loaded into different NLC formulations, through high pressure homogenization, and their in vitro and in vivo effectiveness was analyzed. The encapsulation process did not reduce drug effectiveness since in vitro SCM-NLC and AMK-NLC drug activity was equal to that of the free drugs. As cryoprotectant, trehalose showed better properties than dextran. Instead, positive chitosan coating was discarded due to its limited cost efficiency. Finally, the in vivo study in acute pneumonia model revealed that intraperitoneal administration was superior to the intramuscular route and confirmed that (-) SCM-NLC with trehalose, was the most suitable formulation against an extensively drug-resistant A. baumannii strain. (c) 2020 Elsevier Inc. All rights reserved.
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