期刊
NANOMEDICINE
卷 15, 期 25, 页码 -出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2020-0236
关键词
computed tomography; Fe3O4 magnetite nanoparticles; Gold deposition; MRI; MR-CT-IVUS imaging; multimodal imaging
资金
- Heriot-Watt University
- Deutsche Bildung AG
- CareerConcept AG (FESTO Bildungsfonds)
Aim:To examine the multimodal contrasting ability of gold-dotted magnetic nanoparticles (Au*MNPs) for magnetic resonance (MR), computed tomography (CT) and intravascular ultrasound (IVUS) imaging. Materials & methods:Au*MNPs were prepared by adapting an impregnation method, without using surface capping reagents and characterized (transmission electron microscopy, x-ray diffraction and Fourier-transform infrared spectroscopy) with theirin vitrocytotoxicity assessed, followed by imaging assessments. Results:The contrast-enhancing ability of Au*MNPs was shown to be concentration-dependent across MR, CT and IVUS imaging. The Au content of the Au*MNP led to evident increases of the IVUS signal.Conclusion:We demonstrated that Au*MNPs showed concentration-dependent contrast-enhancing ability in MRI and CT imaging, and for the first-time in IVUS imaging due to the Au content. These Au*MNPs are promising toward solidifying tri-modal imaging-based theragnostics.
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