期刊
NANO LETTERS
卷 20, 期 11, 页码 8141-8150出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.0c03127
关键词
metallic complex; reactive oxygen species; Fenton reaction; tumor redox microenvironment; ferroptosis
类别
资金
- National Natural Science Foundation of China [81773642, 81701817]
- Natural Science Foundation of Guangdong Province [2019A1515011619, 2019A1515011498]
- Guangdong-Hong Kong Technology Cooperation Fund [2017A050506016]
- Key Laboratory of Biomedical Effects of Nanomaterials and Nanosafety
- National Center for Nanoscience and Technology, ACS [NSKF201819]
- Guangdong Basic and Applied Basic Research Foundation [2019A1515110877]
- China Postdoctoral Science Foundation [2020M672542]
The ferroptosis effect has been illuminated with a clear Fenton reaction mechanism that converts endogenous hydrogen peroxide (H2O2) into highly oxidative hydroxyl radicals (center dot OH) in ROS-amplified tumor therapy. This ferroptosis-related oxidation effect was then further enhanced by the enzyme-like roles of cisplatin (CDDP). This CDDP-induced apoptosis was promoted in reverse by ferroptosis via the depletion of glutathione (GSH) and prevention of DNA damage repair. Here, we have developed degradable metallic complexes (PtH@FeP) containing an Fe(III)-polydopamine (FeP) core and HA-cross-linked CDDP (PtH) shell, exaggerating in situ toxic ROS production via the synergistic effect of CDDP and Fe(III). Taken together, the rationally designed PtH@FeP provided a new strategy for self-amplified synergistic chemotherapy/ferroptosis/photothermal therapy (PTT) antitumor effects with a reduced dosage that facilitates clinical safety.
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