期刊
NANO LETTERS
卷 20, 期 10, 页码 7272-7280出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.0c02655
关键词
RGD nanopatches; RGD frequency; macrophage adhesion; macrophage polarization
类别
资金
- National Research Foundation of Korea (NRF) - Korea government (Ministry of Science and ICT) [2020R1C1C1011038, 2019R1A2C3006587]
- Korea University Grant
- Korea Basic Science Institute
- Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF) [ECCS-1542205]
- MRSEC IRG2 program at the Materials Research Center [NSF DMR-1720139]
- International Institute for Nanotechnology (IIN)
- Keck Foundation
- State of Illinois, through the IIN
- National Research Foundation of Korea [2020R1C1C1011038] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Macrophages can associate with extracellular matrix (ECM) demonstrating nanosequenced cell-adhesive RGD ligand. In this study, we devised barcoded materials composed of RGD-coated gold and RGD-absent iron nanopatches to show various frequencies and position of RGD-coated nanopatches with similar areas of iron and RGD-gold nanopatches that maintain macroscale and nanoscale RGD density invariant. Iron patches were used for substrate coupling. Both large (low frequency) and externally positioned RGD-coated nanopatches stimulated robust attachment in macrophages, compared with small (high frequency) and internally positioned RGD-coated nanopatches, respectively, which mediate their regenerative/anti-inflammatory M2 polarization. The nano-barcodes exhibited stability in vivo. We shed light into designing ligand-engineered nanostructures in an external position to facilitate host cell attachment, thereby eliciting regenerative host responses.
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