期刊
NANO LETTERS
卷 20, 期 10, 页码 7220-7229出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.0c02576
关键词
Mesoporous silica nanoparticles; Glutamine; Polydopamine; Islet transplantation; Diabetes; Nutrient delivery
类别
资金
- NIDDK [R01DK119293, P30DK116074]
- Stanford Nano Shared Facilities grant [1161726-146-DAARZ]
- National Science Foundation [ECCS-1542152]
- Stanford Neuroscience Microscopy Service [NIH NS069375]
- Akiko Yamazaki and Jerry Yang Faculty Scholar Fund in Pediatric Translational Medicine
- Stanford Maternal and Child Health Research Institute
In the present study, we created a nanoscale platform that can deliver nutrients to pancreatic islets in a controlled manner. Our platform consists of a mesoporous silica nanoparticle (MSNP), which can be loaded with glutamine (G: an essential amino acid required for islet survival and function). To control the release of G, MSNPs were coated with a polydopamine (PD) layer. With the optimal parameters (0.5 mg/mL and 0.5 h), MSNPs were coated with a layer of PD, which resulted in a delay of G release from MSNPs over 14 d (57.4 +/- 4.7% release). Following syngeneic renal subcapsule islet transplantation in diabetic mice, PDG-MSNPs improved the engraftment of islets (i.e., enhanced revascularization and reduced inflammation) as well as their function, resulting in re-establishment of glycemic control. Collectively, our data show that PDG-MSNPs can support transplanted islets by providing them with a controlled and sustained supply of nutrients.
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