期刊
NANO LETTERS
卷 20, 期 10, 页码 7350-7358出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.0c02767
关键词
antibiofilm; self-propulsion; biofilm penetration; photothermal therapy; synergistic effect
类别
资金
- NSFC [21533008, 91856205, 21871249, 21820102009]
- Key Program of Frontier of Sciences, CAS [QYZDJ-SSW-SLH052]
Increasing penetration of antibacterial agents into biofilm is a promising strategy for improvement of therapeutic effect and slowdown of the progression of antibiotic resistance. Herein, we design a near-infrared (NIR) light-driven nanoswimmer (HSMV). Under NIR light irradiation, HSMV performs efficient self-propulsion and penetrates into the biofilm within 5 min due to photothermal conversion of asymmetrically distributed AuNPs. The localized thermal (similar to 45 degrees C) and thermal-triggered release of vancomycin (Van) leads to an efficient combination of photothermal therapy and chemotherapy in one system. The active motion of HSMV increases the effective distance of photothermal therapy (PTT) and also improves the therapeutic index of the antibiotic, resulting in superior biofilm removal rate (>90%) in vitro. Notably, HSMV can eliminate S. aureus biofilms grown in vivo under 10 min of laser irradiation without damage to healthy tissues. This work may shed light on therapeutic strategies for in vivo treatment of biofilm-associated infections.
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