期刊
NANO LETTERS
卷 20, 期 9, 页码 6235-6245出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.0c00502
关键词
Upconverting nanocarriers; microtubule inhibitor; ferroptosis; triple-negative breast cancer; drug delivery
类别
资金
- National Natural Science Foundation of China [21961142012]
- Tianjin Research Program of Application Foundation and Advanced Technology [18JCZDJC35700, 19JCYBJC28400]
- Science, Technology, and Innovation Commission of Shenzhen Municipality [JCYJ20190806162412752]
Despite the resistance of triple-negative breast cancer (TNBC) to targeted hormone therapy, the discovery of azobenzene combretastatin A4 (Azo-CA4) provides therapeutic opportunities for TNBC. Here, Azo-CA4 was loaded in upconverting nanocarriers that could convert near-infrared (NIR) light to UV light to activate Azo-CA4. Upon irradiation, Azo-CA4-loaded nanocarriers significantly reduced the viability of TNBC cells via both apoptosis and ferroptosis. The former was induced by photoisomerization of Azo-CA4, accompanied by microtubule breakdown and cell cycle arrest at G(2)/M phase. The latter was caused by the UV light-induced reduction of Fe3+ to Fe2+ that facilitates the peroxidation of tailored lipids. The cooperation between apoptosis and ferroptosis in eliminating TNBC was demonstrated in a xenograft mice model in terms of histological staining, tumor growth inhibition, and animal survival. Since the NIR light is only applied to the tumor site, the adverse effects of such triggered nanocarriers to the healthy organs are negligible.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据