期刊
MOLECULES
卷 25, 期 18, 页码 -出版社
MDPI
DOI: 10.3390/molecules25184323
关键词
boronic acids; biological applications; synthesis of boronic acid derivatives; boron-containing compounds
资金
- national funds through FCT - Foundation for Science and Technology [UIDB/04423/2020, UIDB/50006/2020, UIDP/04423/2020, PTDC/SAU-PUB/28736/2017]
- COMPETE 2020, Portugal
- European Union through the ERDF
- FCT through national funds
- Fundação para a Ciência e a Tecnologia [PTDC/SAU-PUB/28736/2017] Funding Source: FCT
Boron containing compounds have not been widely studied in Medicinal Chemistry, mainly due to the idea that this group could confer some toxicity. Nowadays, this concept has been demystified and, especially after the discovery of the drug bortezomib, the interest for these compounds, mainly boronic acids, has been growing. In this review, several activities of boronic acids, such as anticancer, antibacterial, antiviral activity, and even their application as sensors and delivery systems are addressed. The synthetic processes used to obtain these active compounds are also referred. Noteworthy, the molecular modification by the introduction of boronic acid group to bioactive molecules has shown to modify selectivity, physicochemical, and pharmacokinetic characteristics, with the improvement of the already existing activities. Besides, the preparation of compounds with this chemical group is relatively simple and well known. Taking into consideration these findings, this review reinforces the relevance of extending the studies with boronic acids in Medicinal Chemistry, in order to obtain new promising drugs shortly.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据