相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。In Silico Investigation of Bitter Hop-Derived Compounds and Their Cognate Bitter Taste Receptors
Andreas Dunkel et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)
Bitter-Tasting Amino Acids L-Arginine and L-Isoleucine Differentially Regulate Proton Secretion via T2R1 Signaling in Human Parietal Cells in Culture
Verena Stoeger et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)
Chemosensory bitter taste receptors T2R4 and T2R14 activation attenuates proliferation and migration of breast cancer cells
Nisha Singh et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2020)
Gastrointestinal taste receptors: could tastants become drugs?
Maik Behrens et al.
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY (2020)
Chemosensory bitter taste receptors (T2Rs) are activated by multiple antibiotics
Appalaraju Jaggupilli et al.
FASEB JOURNAL (2019)
The human bitter taste receptor TAS2R7 facilitates the detection of bitter salts
Maik Behrens et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)
A role for taste receptors in (neuro)endocrinology?
Maik Behrens et al.
JOURNAL OF NEUROENDOCRINOLOGY (2019)
Metal Ions Activate the Human Taste Receptor TAS2R7
Yi Wang et al.
CHEMICAL SENSES (2019)
A natural point mutation in the bitter taste receptor TAS2R16 causes inverse agonism of arbutin in lemur gustation
Akihiro Itoigawa et al.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2019)
Dual binding mode of bitter sugars to their human bitter taste receptor target
Fabrizio Fierro et al.
SCIENTIFIC REPORTS (2019)
Cellular and Neural Responses to Sour Stimuli Require the Proton Channel Otop1
Bochuan Teng et al.
CURRENT BIOLOGY (2019)
Bitter Taste Receptors for Asthma Therapeutics
Ajay P. Nayak et al.
FRONTIERS IN PHYSIOLOGY (2019)
Sour Sensing from the Tongue to the Brain
Jin Zhang et al.
CELL (2019)
BitterDB: taste ligands and receptors database in 2019
Ayana Dagan-Wiener et al.
NUCLEIC ACIDS RESEARCH (2019)
Vertebrate Bitter Taste Receptors: Keys for Survival in Changing Environments
Maik Behrens et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2018)
Insights into the binding of agonist and antagonist to TAS2R16 receptor: a molecular simulation study
Zhirong Chen et al.
MOLECULAR SIMULATION (2018)
Chemoreceptors in the Gut
S. Steensels et al.
ANNUAL REVIEW OF PHYSIOLOGY, VOL 80 (2018)
Plasticity of the ligand binding pocket in the bitter taste receptor T2R7
Kun Liu et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2018)
Reengineering the ligand sensitivity of the broadly tuned human bitter taste receptor TAS2R14
Stefanie Nowak et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2018)
Structure-Function Relationships of Olfactory and Taste Receptors
Maik Behrens et al.
CHEMICAL SENSES (2018)
An evolutionarily conserved gene family encodes proton-selective ion channels
Yu-Hsiang Tu et al.
SCIENCE (2018)
Characterization of the Binding Sites for Bacterial Acyl Homoserine Lactones (AHLs) on Human Bitter Taste Receptors (T2Rs)
Appalaraju Jaggupilli et al.
ACS INFECTIOUS DISEASES (2018)
Lineage-specific duplication and adaptive evolution of bitter taste receptor genes in bats
Hengwu Jiao et al.
MOLECULAR ECOLOGY (2018)
Intestinal bitter taste receptor activation alters hormone secretion and imparts metabolic benefits
Bernard P. Kok et al.
MOLECULAR METABOLISM (2018)
Role of Taste Receptors as Sentinels of Innate Immunity in the Upper Airway
Neil N. Patel et al.
JOURNAL OF PATHOGENS (2018)
Independent Evolution of Strychnine Recognition by Bitter Taste Receptor Subtypes
Ava Yuan Xue et al.
FRONTIERS IN MOLECULAR BIOSCIENCES (2018)
Extraoral bitter taste receptors in health and disease
Ping Lu et al.
JOURNAL OF GENERAL PHYSIOLOGY (2017)
Ligand binding modes from low resolution GPCR models and mutagenesis: chicken bitter taste receptor as a test-case
Antonella Di Pizio et al.
SCIENTIFIC REPORTS (2017)
The Bitter Taste Receptor TAS2R16 Achieves High Specificity and Accommodates Diverse Glycoside Ligands by using a Two-faced Binding Pocket
Anu Thomas et al.
SCIENTIFIC REPORTS (2017)
Identification of a specific agonist of human TAS2R14 from Radix Bupleuri through virtual screening, functional evaluation and binding studies
Yuxin Zhang et al.
SCIENTIFIC REPORTS (2017)
Functional characterization of the TAS2R38 bitter taste receptor for phenylthiocarbamide in colobine monkeys
Laurentia Henrieta Permita Sari Purba et al.
BIOLOGY LETTERS (2017)
A portable and multiplexed bioelectronic sensor using human olfactory and taste receptors
Manki Son et al.
BIOSENSORS & BIOELECTRONICS (2017)
Variation in ligand responses of the bitter taste receptors TAS2R1 and TAS2R4 among New World monkeys
Kei Tsutsui et al.
BMC EVOLUTIONARY BIOLOGY (2016)
Probing the Binding Pocket of the Broadly Tuned Human Bitter Taste Receptor TAS2R14 by Chemical Modification of Cognate Agonists
Rafik Karaman et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2016)
Bitter taste receptors: Extraoral roles in pathophysiology
Feroz Ahmed Shaik et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2016)
Comprehensive Analysis of Mouse Bitter Taste Receptors Reveals Different Molecular Receptive Ranges for Orthologous Receptors in Mice and Humans
Kristina Lossow et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
The Pharmacochaperone Activity of Quinine on Bitter Taste Receptors
Jasbir D. Upadhyaya et al.
PLOS ONE (2016)
Promiscuity and selectivity of bitter molecules and their receptors
Antonella Di Pizio et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2015)
A functional comparison of the domestic cat bitter receptors Tas2r38 and Tas2r43 with their human orthologs
Michelle M. Sandau et al.
BMC NEUROSCIENCE (2015)
Evidence for a Transient Additional Ligand Binding Site in the TAS2R46 Bitter Taste Receptor
Massimo Sandal et al.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2015)
Functional Analyses of Bitter Taste Receptors in Domestic Cats (Felis catus)
Weiwei Lei et al.
PLoS One (2015)
Bitter taste receptor agonists elicit G-protein-dependent negative inotropy in the murine heart
Simon R. Foster et al.
FASEB JOURNAL (2014)
Tuning Properties of Avian and Frog Bitter Taste Receptors Dynamically Fit Gene Repertoire sizes
Maik Behrens et al.
MOLECULAR BIOLOGY AND EVOLUTION (2014)
Major haplotypes of the human bitter taste receptor TAS2R41 encode functional receptors for chloramphenicol
Sophie Thalmann et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2013)
The Human Bitter Taste Receptor TAS2R10 Is Tailored to Accommodate Numerous Diverse Ligands
Stephan Born et al.
JOURNAL OF NEUROSCIENCE (2013)
CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes
Akiyuki Taruno et al.
NATURE (2013)
Coarse-Grained/Molecular Mechanics of the TAS2R38 Bitter Taste Receptor: Experimentally-Validated Detailed Structural Prediction of Agonist Binding
Alessandro Marchiori et al.
PLOS ONE (2013)
Bitter taste receptor research comes of age: From characterization to modulation of TAS2Rs
Maik Behrens et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2013)
Functional diversity of bitter taste receptor TAS2R16 in primates
Hiroo Imai et al.
BIOLOGY LETTERS (2012)
Identification of Enterodiol as a Masker for Caffeine Bitterness by Using a Pharmacophore Model Based on Structural Analogues of Homoeriodictyol
Jakob P. Ley et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2012)
3D Structure Prediction of TAS2R38 Bitter Receptors Bound to Agonists Phenylthiocarbannide (PTC) and 6-n-Propyithiouracil (PROP)
Jun Tan et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2012)
Constitutively active mutant gives novel insights into the mechanism of bitter taste receptor activation
Sai Prasad Pydi et al.
JOURNAL OF NEUROCHEMISTRY (2012)
Recombinant expression, in vitro refolding, and biophysical characterization of the N-terminal domain of T1R3 taste receptor
Elodie Maitrepierre et al.
PROTEIN EXPRESSION AND PURIFICATION (2012)
Structural Basis of Activation of Bitter Taste Receptor T2R1 and Comparison with Class A G-protein-coupled Receptors (GPCRs)
Nisha Singh et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Structure-function relationships of the human bitter taste receptor hTAS2R1: insights from molecular modeling studies
Weimin Dai et al.
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION (2011)
The human bitter taste receptor, hTAS2R16, discriminates slight differences in the configuration of disaccharides
Takanobu Sakurai et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)
Bitter taste receptor T2R1 is activated by dipeptides and tripeptides
Jasbir Upadhyaya et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)
The Molecular Receptive Ranges of Human TAS2R Bitter Taste Receptors
Wolfgang Meyerhof et al.
CHEMICAL SENSES (2010)
Oligomerization of TAS2R Bitter Taste Receptors
Christina Kuhn et al.
CHEMICAL SENSES (2010)
Modulation of Bitter Taste Perception by a Small Molecule hTAS2R Antagonist
Jay P. Slack et al.
CURRENT BIOLOGY (2010)
Characterization of the β-D-Glucopyranoside Binding Site of the Human Bitter Taste Receptor hTAS2R16
Takanobu Sakurai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
The cell biology of taste
Nirupa Chaudhari et al.
JOURNAL OF CELL BIOLOGY (2010)
The cells and peripheral representation of sodium taste in mice
Jayaram Chandrashekar et al.
NATURE (2010)
Insights into the Binding of Phenyltiocarbamide (PTC) Agonist to Its Target Human TAS2R38 Bitter Receptor
Xevi Biarnes et al.
PLOS ONE (2010)
Identification of non-taster Japanese macaques for a specific bitter taste
Nami Suzuki et al.
PRIMATES (2010)
Structural requirements of bitter taste receptor activation
Anne Brockhoff et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Voltage-gated sodium channels in taste bud cells
Na Gao et al.
BMC NEUROSCIENCE (2009)
Agonist-induced conformational changes in bovine rhodopsin: Insight into activation of G-protein-coupled receptors
Supriyo Bhattacharya et al.
JOURNAL OF MOLECULAR BIOLOGY (2008)
Functions of human bitter taste receptors depend on N-glycosylation
Claudia Reichling et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Crystal structure of opsin in its G-protein-interacting conformation
Patrick Scheerer et al.
NATURE (2008)
Signal transduction and information processing in mammalian taste buds
Stephen D. Roper
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2007)
Broad tuning of the human bitter taste receptor hTAS2R46 to various sesquiterpene lactones, clerodane and labdane diterpenoids, strychnine, and denatonium
Anne Brockhoff et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2007)
3-dimensional structures of G protein-coupled receptors and binding sites of agonists and antagonists
William A. Goddard et al.
JOURNAL OF NUTRITION (2007)
Characterization of ligands for fish taste receptors
Hideaki Oike et al.
JOURNAL OF NEUROSCIENCE (2007)
Modeling the human PTC bitter-taste receptor interactions with bitter tastants
Wely B. Floriano et al.
JOURNAL OF MOLECULAR MODELING (2006)
Members of RTP and REEP gene families influence functional bitter taste receptor expression
Maik Behrens et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Bitter taste receptors and human bitter taste perception
M. Behrens et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2006)
Independent evolution of bitter-taste sensitivity in humans and chimpanzees
S Wooding et al.
NATURE (2006)
Computational studies of ligand-receptor interactions in bitter taste receptors
Laurence Miguet et al.
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION (2006)
ATP signaling is crucial for communication from taste buds to gustatory nerves
TE Finger et al.
SCIENCE (2005)
Distinct contributions of T1R2 and T1R3 taste receptor subunits to the detection of sweet stimuli
Y Nie et al.
CURRENT BIOLOGY (2005)
Identification of Ligands for two human bitter T2R receptors
AN Pronin et al.
CHEMICAL SENSES (2004)
G protein-coupled receptor dimerization: Function and ligand pharmacology
G Milligan
MOLECULAR PHARMACOLOGY (2004)
RTP family members induce functional expression of mammalian odorant receptors
H Saito et al.
CELL (2004)
The human taste receptor hTAS2R14 responds to a variety of different bitter compounds
M Behrens et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
The G-protein-coupled receptors in the human genome form five main families.: Phylogenetic analysis, paralogon groups, and fingerprints
R Fredriksson et al.
MOLECULAR PHARMACOLOGY (2003)
Functional expression of murine V213 pheromone receptors involves selective association with the M10 and M1 families of MHC class Ib molecules
J Loconto et al.
CELL (2003)
The human TAS2R16 receptor mediates bitter taste in response to β-glucopyranosides
B Bufe et al.
NATURE GENETICS (2002)
A transient receptor potential channel expressed in taste receptor cells
CA Pérez et al.
NATURE NEUROSCIENCE (2002)
Human receptors for sweet and umami taste
XD Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Mammalian sweet taste receptors
G Nelson et al.
CELL (2001)
A candidate taste receptor gene near a sweet taste locus
JP Montmayeur et al.
NATURE NEUROSCIENCE (2001)
Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac
M Max et al.
NATURE GENETICS (2001)
Immunocytochemical evidence for co-expression of Type III IP3 receptor with signaling components of bitter taste transduction
Tod R. Clapp et al.
BMC NEUROSCIENCE (2001)
Crystal structure of rhodopsin: A G protein-coupled receptor
K Palczewski et al.
SCIENCE (2000)
G protein βγ complexes in circumvallate taste cells involved in bitter transduction
P Rössler et al.
CHEMICAL SENSES (2000)
A family of candidate taste receptors in human and mouse
H Matsunami et al.
NATURE (2000)
A novel family of mammalian taste receptors
E Adler et al.
CELL (2000)
T2Rs function as bitter taste receptors
J Chandrashekar et al.
CELL (2000)
分享论文
