期刊
MOLECULES
卷 25, 期 17, 页码 -出版社
MDPI
DOI: 10.3390/molecules25173897
关键词
Hirao reaction; P-C coupling; Pd-catalyst; Ni-catalyst; catalyst formation; mechanism; ligation
资金
- National Research, Development, and Innovation Office [K119202, K134318]
The Hirao reaction involving the phosphinoylation or phosphonation of aryl halides by >P(O)H reagents is a P-C bond forming transformation belonging to the recently very hot topic of cross-couplings. The Pd- or Ni-catalyzed variations take place via the usual cycle including oxidative addition, ligand exchange, and reductive elimination. However, according to the literature, the nature of the transition metal catalysts is not unambiguous. In this feature article, the catalysts described for the Pd(OAc)(2)-promoted cases are summarized, and it is concluded that the (HOY2P)(2)Pd(0) species (Y = aryl, alkoxy) is the real catalyst. In our model, the excess of the >P(O)H reagent served as the P-ligand. During the less studied Ni(II)-catalyzed instances the (HOY2P)(-OY2P)Ni(II)Cl- form was found to enter the catalytic cycle. The newest conclusions involving the exact structure of the catalysts, and the mechanism for their formation explored by us were supported by our earlier experimental data and theoretical calculations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据