期刊
MOLECULES
卷 25, 期 16, 页码 -出版社
MDPI
DOI: 10.3390/molecules25163750
关键词
Greigia sphacelata; endemic fruits; UHPLC-PDA-Orbitrap-MS; metabolomic analysis; antioxidant; cholinesterase inhibition
资金
- FONDECYT [1180059]
- CONICYT PFCHA/beca doctorado nacional [2019-21191978]
- CONICYT (PAI/ACADEMIA) [79160109]
- [3190794]
- [3190572]
Greigia sphacelata(Ruiz and Pav.) Regel (Bromeliaceae) is a Chilean endemic plant popularly known as quiscal and produces an edible fruit consumed by the local Mapuche communities named as chupon. In this study, several metabolites including phenolic acids, organic acids, sugar derivatives, catechins, proanthocyanidins, fatty acids, iridoids, coumarins, benzophenone, flavonoids, and terpenes were identified inG. sphacelatafruits using ultrahigh performance liquid chromatography-photodiode array detection coupled with a Orbitrap mass spectrometry (UHPLC-PDA-Orbitrap-MS) analysis for the first time. The fruits showed moderate antioxidant capacities (i.e., 487.11 +/- 26.22 mu mol TE/g dry weight) in the stable radical DPPH assay, 169.08 +/- 9.81 TE/g dry weight in the ferric reducing power assay, 190.32 +/- 6.23 TE/g dry weight in the ABTS assay, and 76.46 +/- 3.18% inhibition in the superoxide anion scavenging assay. The cholinesterase inhibitory potential was evaluated against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). From the findings, promising results were observed for pulp and seeds. Our findings suggest thatG. sphacelatafruits are a rich source of diverse secondary metabolites with antioxidant capacities. In addition, the inhibitory effects against AChE and BChE suggest that natural products or food supplements derived fromG. sphacelatafruits are of interest for their neuroprotective potential.
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