期刊
MOLECULES
卷 25, 期 19, 页码 -出版社
MDPI
DOI: 10.3390/molecules25194354
关键词
flaxseed polysaccharides; simulated digestion; gut microbiota; in vitro fermentation
资金
- Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Agricultural Sciences [1610172019009]
- Natural Science Foundation of Hubei Province [2019CFB342]
- Earmarked Fund for China Agriculture Research System [CARS-14]
- Agricultural Science and Technology Innovation Project of Chinese Academy of Agricultural Sciences [CAAS-ASTIP-2013-OCRI]
The digestion of flaxseed polysaccharides (FSP) in simulated saliva, gastric and small intestine conditions was assessed, as well as in vitro fermentation of FSP by human gut microbiota. FSP was not degraded in the simulated digestive systems (there was no change in molecular weight or content of reducing sugars), indicating that ingested FSP would reach the large intestine intact. Changes in carbohydrate content, reducing sugars and culture pH suggested that FSP could be broken down and used by gut microbiota. FSP modulated the composition and structure of the gut microbiota by altering the Firmicutes/Bacteroidetes ratio and increasing the relative abundances of Prevotella, Phascolarctobacterium, Clostridium and Megamonas, which can degrade polysaccharides. Meanwhile, FSP fermentation increased the concentration of short-chain fatty acids, especially propionic and butyric acids. Our results indicate that FSP might be developed as a functional food that benefits gut health.
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