期刊
MOLECULAR IMMUNOLOGY
卷 126, 期 -, 页码 25-30出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2020.07.006
关键词
Lymphoid; Myeloid; pDC; Development; Hematopoiesis
资金
- SNF [PP00P3_179056, 310030_185193]
- Intramural Research Program of the NIH, NIDCR
- Swiss National Science Foundation (SNF) [310030_185193, PP00P3_179056] Funding Source: Swiss National Science Foundation (SNF)
- NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH [ZIADE000752] Funding Source: NIH RePORTER
Plasmacytoid dendritic cells (pDCs) are an immune subset specialized in the production of Type I Interferons (IFNs). They are characterized by co-expression of myeloid and lymphoid markers. Their developmental origin has been studied since their discovery and the identification of a myeloid progenitor capable of generating all dendritic cell (DC) subsets, including pDCs, led to their classification within the myeloid compartment. However, recent findings challenge this hypothesis and provide evidence for a lymphoid origin for the majority of pDCs (46-48). In this review we discuss and present the original myeloid and the newer lymphoid developmental trajectories of pDCs.
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