Marker genotyping error effects on genomic predictions under different genetic architectures

This study aimed to determine the effect of different rates of marker genotyping error on the accuracy of genomic prediction that was examined under distinct marker and quantitative trait loci (QTL) densities and different heritability estimates using a stochastic simulation approach. For each scenario of simulation, a reference population with phenotypic and genotypic records and a validation population with only genotypic records were considered. Marker effects were estimated in the reference population, and then their genotypic records were used to predict genomic breeding values in the validation population. The prediction accuracy was calculated as the correlation between estimated and true breeding values. The prediction bias was examined by computing the regression of true genomic breeding value on estimated genomic breeding value. The accuracy of the genomic evaluation was the highest in a scenario with no marker genotyping error and varied from 0.731 to 0.934. The accuracy of the genomic evaluation was the lowest in a scenario with marker genotyping error equal to 20% and changed from 0.517 to 0.762. The unbiased regression coefficients of true genomic breeding value on estimated genomic breeding value were obtained in the reference and validation populations when the rate of marker genotyping error was equal to zero. The results showed that marker genotyping error can reduce the accuracy of genomic evaluations. Moreover, marker genotyping error can provide biased estimates of genomic breeding values. Therefore, for obtaining accurate results it is recommended to minimize the marker genotyping errors to zero in genomic evaluation programs.

Automated summary

This study investigated the impact of different rates of marker genotyping error on the accuracy of genomic prediction using stochastic simulation. The results showed that marker genotyping error can decrease the accuracy of genomic evaluations and result in biased estimates of genomic breeding values. It is recommended to minimize marker genotyping errors to zero in genomic evaluation programs in order to obtain accurate results.