期刊
MOLECULAR DIVERSITY
卷 25, 期 4, 页码 2441-2446出版社
SPRINGER
DOI: 10.1007/s11030-020-10146-7
关键词
Domino reaction; Pyrroloisoquinolines; Unsaturated ketones; Nitriles; Nitroalkenes
类别
资金
- RUDN University Program 5-100
- Ministry of Science and Higher Education of the Russian Federation
A convenient protocol for the synthesis of 5,6-dihydropyrrolo[2,1-a]isoquinolines with various electron-withdrawing substituents at C-2 atom is described. This approach is based on the two-component domino reaction of 1-aroyl-3,4-dihydroisoquinolines with alpha,beta-unsaturated ketones, nitroalkenes and acrylonitrile. Depending on the selected substrates, the reaction was performed in TFE under reflux or under microwave irradiation. Only for the two examples, a transition metal catalyst was used.
A convenient protocol for the synthesis of 5,6-dihydropyrrolo[2,1-a]isoquinolines with various electron-withdrawing substituents at C-2 atom is described. This approach is based on the two-component domino reaction of 1-aroyl-3,4-dihydroisoquinolines with alpha,beta-unsaturated ketones, nitroalkenes and acrylonitrile. Depending on the selected substrates, the reaction was performed in TFE under reflux or under microwave irradiation. Only for the two examples, a transition metal catalyst was used.
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