Log Transformation Improves Dating of Phylogenies

Phylogenetic trees inferred from sequence data often have branch lengths measured in the expected number of substitutions and therefore, do not have divergence times estimated. These trees give an incomplete view of evolutionary histories since many applications of phylogenies require time trees. Many methods have been developed to convert the inferred branch lengths from substitution unit to time unit using calibration points, but none is universally accepted as they are challenged in both scalability and accuracy under complex models. Here, we introduce a new method that formulates dating as a nonconvex optimization problem where the variance of log-transformed rate multipliers is minimized across the tree. On simulated and real data, we show that our method, wLogDate, is often more accurate than alternatives and is more robust to various model assumptions.

Automated summary

This paper introduces a new dating method wLogDate, which formulates dating as a nonconvex optimization problem, minimizing the variance of log-transformed rate multipliers across the tree. The method is shown to be more accurate and robust to various model assumptions than alternatives on simulated and real data.