期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 515, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2020.110930
关键词
Progesterone; Corpus luteum; Steroidogenesis; Granulosa cell; Endocrine disrupting chemicals
资金
- Reproductive Scientist Development Program (NIH-NICHD Project) [2K12HD000849-26]
- American Society for Reproductive Medicine
- Albert McKern Scholar Award
- NIH Loan Repayment Program
- National Institutes of Health/National Institute of Environmental Health Sciences (NIH/NIEHS) [R00 ES022983]
Progesterone, a critical hormone in reproduction, is a key sex steroid in the establishment and maintenance of early pregnancy and serves as an intermediary for synthesis of other steroid hormones. Progesterone production from the corpus luteum is a tightly regulated process which is stimulated and maintained by multiple factors, both systemic and local. Multiple regulatory systems, including classic mediators of gonadotropin stimulation such as the cAMP/PKA pathway and TGFp-mediated signaling pathways, as well as local production of hormonal factors, exist to promote granulosa cell function and physiological fine-tuning of progesterone levels. In this manuscript, we provide an updated narrative review of the known mediators of human luteal progesterone and highlight new observations regarding this important process, focusing on studies published within the last five years. We will also review recent evidence suggesting that this complex system of progesterone production is sensitive to disruption by exogenous environmental chemicals that can mimic or interfere with the activities of endogenous hormones.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据