期刊
MOLECULAR AND CELLULAR BIOCHEMISTRY
卷 476, 期 2, 页码 785-796出版社
SPRINGER
DOI: 10.1007/s11010-020-03944-y
关键词
OSCC; MMP1 3′ UTR; miR-188-5p; ceRNA; CDK4; SOX4
类别
资金
- Joint Funds for the innovation of Science and Technology, Fujian province [2018Y9012]
The study reveals the involvement of MMP1 mRNA in oral squamous cell carcinoma through a ceRNA regulatory mechanism, mediating a regulatory network among MMP1, SOX4, and CDK4, which may offer a novel avenue for target therapy.
Growing evidence indicates that the non-coding 3 '-untranslated region (3 ' UTR) of genes acts as competing endogenous RNAs (ceRNAs) to exert their roles in a number of diseases, including cancer. In the present study, MMP1 messenger RNA was identified to be significantly up-regulated in oral squamous cell carcinoma (OSCC) tissues, and both MMP1 and its 3 ' UTR promoted tumor growth and cell motility. Further mechanism investigations indicated that MMP1 3 ' UTR was able to antagonize miR-188-5p; in addition, overexpression of MMP1 3 ' UTR up-regulated the expression level of SOX4 and CDK4, target genes of miR-188-5p, which have also been identified as oncogenic driver genes in OSCC. Therefore, a ceRNA regulatory network among MMP1, SOX4, and CDK4 mediated via competing for binding to miR-188-5p was proved. Taken together, the present study demonstrates for the first time that MMP1 mRNA participates in the development of OSCC via ceRNA regulatory mechanism and genes involved in the ceRNA network may provide a novel avenue for target therapy.
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