期刊
MOLECULAR AND CELLULAR BIOCHEMISTRY
卷 476, 期 1, 页码 231-246出版社
SPRINGER
DOI: 10.1007/s11010-020-03900-w
关键词
Circular RNA; Stem cells; Cell differentiation; Cell proliferation; Apoptosis
类别
资金
- National Natural Science Foundation of China [81700938, 81670957, 81772876]
- Beijing Natural Science Foundation [7172239]
Circular RNAs have unique expression profiles in stem cell differentiation and can serve as promising biomarkers. Key circRNAs are involved in the differentiation, proliferation, and apoptosis of stem cells through mechanisms like sponging miRNAs.
Circular RNAs(circRNAs) are a large family of RNAs shaping covalently closed ring-like molecules and have become a hotspot with thousands of newly published studies. Stem cells are undifferentiated cells and have great potential in medical treatment due to their self-renewal ability and differentiation capacity. Abundant researches have unveiled that circRNAs have unique expression profile during the differentiation of stem cells and could serve as promising biomarkers of these cells. There are key circRNAs relevant to the differentiation, proliferation, and apoptosis of stem cells with certain mechanisms such as sponging miRNAs, interacting with proteins, and interfering mRNA translation. Moreover, several circRNAs have joined in the interplay between stem cells and lymphocytes. Our review will shed lights on the emerging roles of circRNAs in regulating the fate of diverse stem cells.
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