期刊
MINI-REVIEWS IN ORGANIC CHEMISTRY
卷 18, 期 6, 页码 735-768出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1570193X17999201012182001
关键词
Quinoline; anti-cancer agents; quinoline derivatives; synthetic procedures; pharmacological effects of quinoline derivatives; benzene ring
Quinoline and its derivatives show high activity against various cancer cells and can serve as potential lead compounds for anticancer drug research. These drugs have potential therapeutic effects on various cancers such as prostate cancer and breast cancer.
New drugs introduced in the market each year, have privileged structures specifically for anticancer targets, of which quinoline-based analogues also play an important role. This review highlights quinoline and its derivatives, which have great potency against various cancer cells, including prostate cancer, breast cancer, colon cancer, pancreas cancer, and many more. This review describes the most preferred process-scale synthetic approaches of quinoline and its derivatives having a specific pharmacophore for anticancer targets. It also describes the undergoing development and recently approved drugs in tabular form. Quinoline moiety as a privileged structural pharmacophore has the most effective activity against different cancer cell lines like prostate cancer, breast cancer, stomach cancer, pancreas cancer, Colon cancer, CNS cancer, and renal cancer. It can be used as a lead compound for further research on anticancer drug discovery.
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