期刊
MICROCHEMICAL JOURNAL
卷 160, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.microc.2020.105521
关键词
CuCo2O4; Reduced graphene oxide; Hydrogen peroxide; Cells; Electrochemical sensor
资金
- National Natural Science Foundation of China [81772290]
- Fundamental Research Funds for the Central Universities [2019CDYGZD007]
- Graduate Scientific Research and Innovation Foundation of Chongqing, China [CYB19041]
- Chongqing science and technology commission [CSTC2018jcyjAX0062]
- Chongqing Graduate Tutor Team Construction Project, Analytical and Testing Center of Chongqing University
- Chongqing University
In this study, CuCo2O4/rGO composites with excellent electrocatalytic performance were successfully synthesized and used for real-time detection of H2O2 released from living cells, demonstrating their potential application in monitoring critical pathological processes in living cells.
Real-time monitoring of hydrogen peroxide (H2O2) released from living tumor cells is still a huge challenge. Herein, reduced graphene oxide supported dumbbell-shaped CuCo2O4 (CuCo2O4/rGO) was prepared via a facile hydrothermal procedure and an annealing treatment. The CuCo2O4/rGO possess intrinsic peroxidase-like activity, while the 3D dumbbell-shaped sructure consisting of 2D nanosheet layers with large surface area and high conductivity can efficiently enhance electrocatalytic performance of the composites. The CuCo2O4/rGO modified glassy carbon electrode (CuCo2O4/rGO/GCE) exhibited good electrocatalytic performances toward H2O2 with a sensitivity about 320.3 mu A mM(-1) cm(-2) and a low detection limit of 80 nM in a linear range of 30-5010 mu M. Furthermore, the CuCo2O4/rGO/GCE electrochemical sensor was successfully used for real-time detection of H2O2 released from living cells, indicating the potential application of CuCo2O4/rGO in monitoring the critical pathological process in living cells.
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