期刊
MEDICAL HYPOTHESES
卷 143, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.mehy.2020.109843
关键词
SARS-CoV-2; Corona; COVID-19; Diethyl carbamazine DEC
SARS-CoV-2 virus has resulted in a devastating pandemic of COVID-19. Exploring compounds that could offer a breakthrough in treatment is the need of the hour. Re-positioning cheap, freely available and safe drugs is a priority. The paper proposes evidence for the potential use of diethylcarbamazine (DEC) in the treatment of COVID-19. DEC has inhibitory effects on arachidonic acid metabolism to prostaglandins, little known anti-viral effects on animal retroviruses and demonstrated anti-inflammatory actions in animal models of lung inflammation indicating the need to explore this hypothesis further. We believe this is the first time DEC is being proposed to treat COVID-19.
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