期刊
MEDICAL HYPOTHESES
卷 142, 期 -, 页码 -出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.mehy.2020.109735
关键词
Alveolar echinococcosis (AE); Tumor; Potassium; Adoptive transfer of T cell
Recently, it is found that there is high concentration of potassium in tumor interstitial fluid, which causes T cell exhaustion and even autophagy of lymphocytes in tumors. The immune mechanism of the late stage of alveolar echinococcosis (AE) is similar to that of tumor immunity. We speculate that the growth and development of the worm body, the necrosis of the worm body and the release of high concentrations of potassium after hepatocyte necrosis in the pathological process of AE may cause T cell exhaustion in AE patients. If this assumption can be confirmed experimentally, T cell adoptive transfer around the AE infiltration zone will be utilized to assist the treatment of AE patients with complex conditions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据