期刊
MECHANISMS OF AGEING AND DEVELOPMENT
卷 190, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mad.2020.111325
关键词
Machine learning; Deep learning; Multimorbidity; Electronic health records; Phenotyping
资金
- Oxford Martin School (OMS)
- National Institute for Health Research (NIHR)Oxford Biomedical Research Centre (BRC)
- PEAK Urban programme - UKRI's Global Challenge Research Fund [ES/P011055/1]
- British Heart Foundation [PG/18/65/33872]
- ESRC [ES/P011055/1] Funding Source: UKRI
The prevalence of multimorbidity has been increasing in recent years, posing a major burden for health care delivery and service. Understanding its determinants and impact is proving to be a challenge yet it offers new opportunities for research to go beyond the study of diseases in isolation. In this paper, we review how the field of machine learning provides many tools for addressing research challenges in multimorbidity. We highlight recent advances in promising methods such as matrix factorisation, deep learning, and topological data analysis and how these can take multimorbidity research beyond cross-sectional, expert-driven or confirmatory approaches to gain a better understanding of evolving patterns of multimorbidity. We discuss the challenges and opportunities of machine learning to identify likely causal links between previously poorly understood disease associations while giving an estimate of the uncertainty on such associations. We finally summarise some of the challenges for wider clinical adoption of machine learning research tools and propose some solutions.
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