期刊
MECHANICS RESEARCH COMMUNICATIONS
卷 112, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.mechrescom.2020.103604
关键词
Fluid-structure interaction; Immersogeometric analysis; Cardiac biomechanics and hemodynamics; Bioprosthetic heart valves; Aortic and mitral valve replacement
类别
资金
- National Heart, Lung, and Blood Institute of the National Institutes of Health [R01HL129077, R01HL142504, R01HL131753]
- National Science Foundation [1750865]
- Direct For Computer & Info Scie & Enginr
- Office of Advanced Cyberinfrastructure (OAC) [1750865] Funding Source: National Science Foundation
This study utilizes computational fluid-structure interaction to model the effects of replacing the aortic and mitral valves in the left ventricle, showing that replacing the mitral valve with a bioprosthesis significantly alters ventricular hemodynamics, causing a reverse vortical motion. The research demonstrates the capability of the proposed computational FSI framework in simulating complex multiphysics problems and providing a detailed understanding of cardiac mechanics.
The left ventricle of the heart is a fundamental structure in the human cardiac system that pumps oxygenated blood into the systemic circulation. Several valvular conditions can cause the aortic and mitral valves associated with the left ventricle to become severely diseased and require replacement. However, the clinical outcomes of such operations, specifically the postoperative ventricular hemody-namics of replacing both valves, are not well understood. This work uses computational fluid-structure interaction (FSI) to develop an improved understanding of this effect by modeling a left ventricle with the aortic and mitral valves replaced with bioprostheses. We use a hybrid Arbitrary Lagrangian- Eulerian/immersogeometric framework to accommodate the analysis of cardiac hemodynamics and heart valve structural mechanics in a moving fluid domain. The motion of the endocardium is obtained from a cardiac biomechanics simulation and provided as an input to the proposed numerical framework. The results from the simulations in this work indicate that the replacement of the native mitral valve with a tri-radially symmetric bioprosthesis dramatically changes the ventricular hemodynamics. Most signif-icantly, the vortical motion in the left ventricle is found to reverse direction after mitral valve replace-ment. This study demonstrates that the proposed computational FSI framework is capable of simulating complex multiphysics problems and can provide an in-depth understanding of the cardiac mechanics. (c) 2020 Elsevier Ltd. All rights reserved.
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