期刊
出版社
ELSEVIER
DOI: 10.1016/j.msec.2020.111028
关键词
PD; Gold nanoparticle composites; Motor-disorders; Cognitive-impairment; LTP
资金
- National Natural Science Foundation of China [31370967]
- Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme, China
- Science and Technology Planning Project of Guangdong Province, China [2015A020212033]
- Guangzhou Science and Technology Program key projects, China [201805010002]
Parkinson's disease (PD) is characterized by motor and non-motor symptoms, primarily affecting dopaminergic neurons (DAergic neurons) in substantia nigra (SN). However, it is still very challenging to identify new drugs that not only inhibit motor dysfunction but also improve non-motor dysfunction. It has been identified as a potential PD treatment that the inhibition of a-syn aggregation could decrease the death of DAergic neurons in SN. In this study, we synthesized gold nanoparticle composites (NPs) that were loaded with plasmid DNA (pDNA) to inhibit a-syn expression. In vivo, our results showed that NPs improved tyrosine hydroxylase (TH) levels and decreased aggregation of a-syn in the SN. Additionally, NPs attenuated motor dysfunction and exploration ability declined. Moreover, NPs reversed the inhibition of long-term potentiation (LTP) and improved non-motor dysfunction in PD mice. These results indicated that NPs had significantly neuroprotective effects not only in motor, but also in non-motor dysfunction to PD mice, providing a new strategy for gene therapy in PD.
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