期刊
出版社
ELSEVIER
DOI: 10.1016/j.msec.2020.111644
关键词
Carbon dots; Yellow-fluorescent; Hydrothermal and reflux method; Multifaceted sensing probe; Ca2+ ion detection; Extracellular sensing
资金
- R&D Program from the Society of the National Research Foundation (NRF) - Ministry of Science, ICT & Future Planning [2015M3A9E2031372]
- Gachon University [GCU-2019-0385]
A novel yellow-fluorescent carbon dots designed for sensing calcium ions exhibit excellent fluorescence properties and have potential application prospects.
Calcium (Ca2+) as a signaling ion and intracellular second messenger plays a crucial role in living organisms for various cellular functions. In the present work, we have designed a novel yellow-fluorescent carbon dots (LERCDs) using lanthanum, ethylenediaminetetraacetic acid (EDTA), and rutin as precursors for the sensing of Ca2+ ions. In this sense, a combination of hydrothermal and reflux methods was adopted. The as-designed LERCDs display bright yellow color emission in the aqueous solutions with a high quantum yield (23.8%). The LERCDs showed excitation-independent emission property along with magnificent photostability and time stability. The LERCDs show potential fluorescence quenching response towards the Ca2+ ions in the concentration range of 0-25 mu M with a detection limit of 2.19 mu M. The LERCDs have studied for extracellular sensing of Ca2+ ions in both melanoma cell lines (A375) and onion epidermal cells by employing fluorescence microscopy. The LERCDs facilitate low cytotoxicity and superior biocompatibility features in A375 cells. The practicality of LERCDs was studied in biological samples like the human serum.
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