期刊
MARINE DRUGS
卷 18, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/md18090446
关键词
cyanobacteria; aeruginosamides; Limnoraphis; cytotoxicity
资金
- National Science Centre in Poland [NCN 2016/21/B/NZ9/02304]
- Institute of Oceanology, PAS [II.3]
Cyanobactins are a large family of ribosomally synthesized and post-translationally modified cyanopeptides (RiPPs). Thus far, over a hundred cyanobactins have been detected in different free-living and symbiotic cyanobacteria. The majority of these peptides have a cyclic structure. The occurrence of linear cyanobactins, aeruginosamides and virenamide, has been reported sporadically and in few cyanobacterial taxa. In the current work, the production of cyanobactins byLimnoraphissp. CCNP1324, isolated from the brackish water Baltic Sea, has been studied for the first time. In the strain, eighteen new aeruginosamide (AEG) variants have been detected. These compounds are characterized by the presence of prenyl and thiazole groups. A common element of AEGs produced byLimnoraphissp. CCNP1324 is the sequence of the three C-terminal residues containing proline, pyrrolidine and methyl ester of thiazolidyne-4-carboxylic acid (Pro-Pyr-TzlCOOMe) or thiazolidyne-4-carboxylic acid (Pro-Pyr-TzlCOOH). The aeruginosamides with methylhomotyrosine (MeHTyr(1)) and with the unidentifiedN-terminal amino acids showed strong cytotoxic activity against human breast cancer cells (T47D).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据